Why Is Lisinopril Bad For African American?

Why are ACE inhibitors less effective in black patients?

‖ACE inhibitors are less effective because of aldosterone escape via non-ACE pathways, such as chymase and cathepsin; renin inhibitors are seldom used.

Evidence supporting this approach is now available from a clinical trial in hypertension clinics in Nigeria, Kenya, and South Africa..

When should I stop taking lisinopril?

If you get severe diarrhoea or vomiting from a stomach bug or illness, tell your doctor. You may need to stop taking lisinopril for a while until you feel better. Drinking alcohol with lisinopril can make you feel dizzy or lightheaded. Lisinopril is also called by the brand name Zestril.

What is the safest blood pressure medicine for the elderly?

ARBs are considered the alternative first-line treatment for hypertension in the elderly population when a diuretic is contraindicated. In elderly hypertensive patients with diabetes or HF, ARBs are considered first-line treatment and an alternative to ACE inhibitors.

Are beta blockers good for African American?

ACE inhibitors and beta blockers are less effective when used as monotherapy in Black hypertensives, especially when used at low doses, although the combination of either of these drugs with a diuretic eliminates some of the ethnic differences between Blacks and non-Blacks.

Which of the following is a common side effect of ACE inhibitors?

ACE inhibitors and bradykinin ACE inhibitors block the breakdown of bradykinin, causing levels of this protein to rise and blood vessels to widen (vasodilation). Increased bradykinin levels are also responsible for the most common side effect of ACE inhibitor treatment; a dry cough.

Why does lisinopril cause angioedema in African American?

The mechanism of ACE inhibitor-associated angioedema is not known, although a plausible mechanism involves the vasoactive peptide bradykinin [6, 7]. The increased risk in black patients may be related to racial differences in the kallikrein-kinin system and increased sensitivity to bradykinin [8].

Is angioedema a side effect of lisinopril?

Angiotensin-converting enzyme (ACE) inhibitors are commonly used in the treatment of hypertension. Angioedema is a known side effect of ACE inhibitors.

How common is angioedema with lisinopril?

Like any prescription medications, there are potential side effects from ACE inhibitors, angioedema being one of the most serious. Angioedema is estimated to occur in 0.1%–0.7% of patients on ACE inhibitor therapy.

What are the 4 worst blood pressure medicines?

6 Outdated High Blood Pressure Medications You Should Consider UpgradingAtenolol. … Furosemide (Lasix) … Nifedipine (Adalat, Procardia) … Terazosin (Hytrin) and Prazosin (Minipress) … Hydralazine (Apresoline) … Clonidine (Catapres)May 23, 2018

Is lisinopril really made from snake venom?

The creation of Lisinopril has an interesting history that dates back to the 1960’s when the very first ACE inhibitors were discovered. Curiously, the ACE inhibitors trace their roots back to snake venom.

What is the first drug of choice for hypertension?

The strongest body of evidence indicates that for most patients with hypertension, thiazide diuretics are the best proven first-line treatment in reducing morbidity and mortality.

What is the best blood pressure medicine for African American?

Calcium channel blockers, namely amlodipine (Norvasc), or the less often prescribed felodipine, are also recommended as first choice to control blood pressure, specifically in African Americans.

What are the side effects of long term use of lisinopril?

Long-TermSwelling in the face, throat, hands, feet, ankles, or lower legs.Difficulty breathing or swallowing, which can indicate a serious allergic reaction.Hoarseness.Jaundice (yellowing of the skin and eyes due to liver damage)Fainting or lightheadedness.Chest pain.Aug 1, 2019

What can replace lisinopril?

ARBs like losartan do not cause a cough and are often a good alternative. Otherwise, lisinopril and losartan have fairly similar side effects to other ACE inhibitors and ARBs.

What is the safest blood pressure medication with the least side effects?

Thiazide diuretics generally have fewer side effects than the others. This is especially true when they’re prescribed in the low doses that are generally used in treating early high blood pressure. Examples of thiazide diuretics include: chlorthalidone (Hygroton)

What is safest blood pressure medication?

Methyldopa, which works to lower blood pressure through the central nervous system, has the lowest risk of harming the mother and developing fetus. Other possible safe options include labetalol, beta-blockers, and diuretics.

What is wrong with lisinopril?

Lisinopril may rarely cause serious (possibly fatal) liver problems. Get medical help right away if you have any symptoms of liver damage, such as: nausea/vomiting that doesn’t stop, loss of appetite, stomach/abdominal pain, yellowing eyes/skin, dark urine. A very serious allergic reaction to this drug is rare.

Can lisinopril cause heart failure?

If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys resulting in a stroke, heart failure, or kidney failure.